Symposium: Nutrition, Biochemisty and Molecular Biology of Biotin Molecular Biology of Biotin Attachment to Proteins
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چکیده
Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the “biotin domain”) with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification. Both biotin domains and biotin protein ligases are very strongly conserved throughout biology. This review concerns the protein structures and mechanisms involved in the covalent attachment of biotin to proteins. J. Nutr. 129: 477S–484S, 1999.
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تاریخ انتشار 1999